Chemical Class: A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. , Procainamide is structurally similar to procaine, but in place of an ester group, procainamide contains an amide group. SOC. Tags: buy Procaine HCl | Procaine HCl supplier | purchase Procaine HCl | Procaine HCl cost | Procaine HCl manufacturer | order Procaine HCl | Procaine HCl distributor, Choose Selective Sodium Channel Inhibitors, In vivo Formulation Calculator (Clear solution), Antineoplastic and Immunosuppressive Antibiotics, Selection Antibiotics for Transfected Cell, FDA-approved & Passed Phase I Drug Library, Human Endogenous Metabolite Compound Library, Anti-cancer Compound Library (Verified by Broad Institute), Anti-Cardiovascular Disease Compound Library, Cytoskeletal Signaling Pathway Compound Library, Endoplasmic Reticulum Stress Compound Library, Protein-protein Interaction Inhibitor Library, Small Molecule Immuno-Oncology Compound Library.
Procaine pretreatment inhibits JAK2 and STAT3 expression. Procaine is a local anesthetic drug of the amino ester group.
J. Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM. These were the cardiac glycosides, quinidine, propranolol, lidocaine and diphenylhydantoin. , Procainamide belongs to the aminobenzamides. Most of these side effects may occur due to the acetylation of procainamide.
Procaine was first synthesized in 1898, and was the first injectable man-made local anesthetic. ref.  All these adverse features stimulated the search for an alternative to procaine.
( click the link to review the publication ). integr.  For example, it can be used to convert new-onset atrial fibrillation, though it is suboptimal for this purpose. Answers to questions you may have can be found in the inhibitor handling instructions. There are two phenotypes that result from the acetylation process, namely the slow and rapid acetylator. Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure. Verdinexor (KPT-335) is an orally bioavailable, selective XPO1/CRM1 inhibitor. (1 u is equal to 1/12 the mass of one atom of carbon-12)  These negative characteristics slowed the search for new antiarrhythmics based on the chemical structure of procainamide. Calculate the dilution required to prepare a stock solution. If you have any other enquiries, please leave a message. Not for human use. Owing to the ubiquity of the trade name Novocain, procaine is usually referred to generically as novocaine. Products are for research use only.  It was launched by Bristol-Myers Squibb in 1951. ). The adverse effects occur even more often if the daily doses are increased.
This led to research for a new antiarrhythmic drug. Procaine HCl purchased from Selleck. , It is administered by mouth, by intramuscular injection, or intravenously. Method for preparing DMSO master liquid: ： mg Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment), Drug: Chloroprocaine 1% Injectable Solution. Procaine facilitates transmission of evoked excitatory activity from the amygdala to the ventromedial hypothalamus. Procaine does not reduce the single channel conductance nor appreciably shorts the mean open times of the channel, rather, it increases the longest closed time. Procainamide is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias.It is classified by the Vaughan Williams classification system as class Ia; thus it is a sodium channel blocker of cardiomyocytes.In addition to blocking the I Na current, it inhibits the I Kr rectifier K+ current. C10H16N2O2 c10h16n2o2. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. STAT3, signal transducer and activator of transcription 3. Biomol Ther (Seoul), 2016, 24(5): 489-494.. It was found that procainamide was effective for treating ventricular arrhythmias, but it had the same toxicity profile as quinidine, and it could cause systemic lupus erythematosus-like syndrome. Procaine hydrochloride is benzoic acid, 4-amino-, 2-(diethylamino) ethyl ester, monohydrochloride, the ester of diethylaminoethanol and para-aminobenzoic acid, with the following structural formula: It is a white crystalline, odorless powder that is …
Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values.  * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM). (A) Relative Jak2 mRNA level detected by qRT-PCR.  Procainamide is also known to induce a voltage-dependent open channel block on the batrachotoxin (BTX)-activated sodium channels in cardiomyocytes. Due to its charged and hydrophilic form, procainamide has its effect from the internal side, where it causes blockage of voltage-dependent, open channels. Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Biophys J, 1993, 64(4), 991-1. Neuropharmacology, 1994, 33(12), 1573-1579. Electroencephalogr Clin Neurophysiol, 1975, 38(4), 355-365. Next day delivery by 10:00 a.m. Order now. N-acetyl-4-aminobenzoic acid as well as N-acetyl-3-hydroxyprocainamide, N-acetylprocainamide-N-oxide and N-acetyl-4-aminohippuric acid are also metabolites of procainamide. Procainamide can also be oxidized by the cytochrome P-450 to a reactive oxide metabolite. Similar concentrations of Procaine normalize the viscosity and filterability, but have no effect on cell volume, osmotic fragility, or monovalent cation composition of cells undergoing ATP depletion. *p<0.05, **p<0.01. , It was also detected that the antiarrhythmic drug procainamide interferes with pacemakers. Procaine influences red cell shape and deformability. , There are many side effects following the induction of procainamide. 45 mM Procaine almost completely prevents the discocyte-echinocyte transformation associated with ATP depletion. sham, rats undergone sham surgery. Hippocampus, 1993, 3(4), 517-525. This substitution is the reason why procainamide exhibits a longer half-life time than procaine. (Index, Outline).  Procainamide hydroxylamine has more cytotoxicity by hindering the response of lymphocytes to T-cell and B-cell mitogens. There is also a chance that drug-induced lupus erythematosus occurs, which at the same time leads to arthralgia, myalgia and pleurisy. About 1 in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity. The hydroxylamine and nitroso metabolites are also toxic to bone marrow cells and can cause agranulocytosis. Chemical Formula: C 12 H 20 N 2 O 2 Molar Mass: 236.31g/mol IUPAC Name: 2-(diethylamino)ethyl 4-aminobenzoate In 1970 only five drugs were reported. GAPDH is used as an internal reference. Br J Anaesth, 2006, 96(1), 77-87. Rufinamide (CGP 33101) is a voltage-gated sodium channel blocker, used an anticonvulsant medication. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.   Adamec RE, et al. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. Procainamide is present in charged form and probably requires a direct hydrophobic access to the binding site for blocking of the channel. As a result, procaine was discovered, which has similar cardiac effects as quinidine. , InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17), para-amino-N-2-(diethylamino)ethyl-benzamide, "Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation", "Use of procainamide gels in the purification of human and horse serum cholinesterases", "Drugs at FDA: FDA Approved Drug Products", "Center for Drug Evaluation and Research Approval Package For: Application Number NDA 20-545/S007", https://en.wikipedia.org/w/index.php?title=Procainamide&oldid=984408209, Creative Commons Attribution-ShareAlike License, This page was last edited on 19 October 2020, at 23:28.  Esposito M, et al. Tween 80，mix and clarify, next add μL ddH2O，mix and clarify. drug pre-dissolved in μL DMSO (Master liquid concentration © Copyright 2013 Selleck Chemicals.
(D) Relative protein levels of JAK2 and STAT3 based on Western blot results.  2002, Issue 124, p.3661-3668, https://psychology.wikia.org/wiki/Procaine?oldid=94314, Hahn-Godeffroy, J.D. Ex18 in U.S. Patent 7,115,750 . JAK2, Janus kinase 2. Procaine, Tetracaine, Chloroprocaine, Benzocaine, Bupivacaine, Lidocaine, Mepivacaine, Prilocaine, Cinchocaine, Etidocaine, Articaine, Ropivacaine, Levobupivacaine, Hexylcaine, Iontocaine, Lidocaine/prilocaine, Shigeki Isomura, Timothy Z. Hoffman, Peter Wirsching, and Kim D. Janda. In certain lines, the para-amino group might become a target site to attach further paraphernalia, e.g. DMSO master liquid,next add μL Corn oil，mix and clarify. It was created by the German chemist Alfred Einhorn (1857–1917) who gave the chemical the trade name Novocaine, from the Latin Novus (meaning New) and caine, a common ending for alkaloids used as anesthetics. It is used primarily to reduce the pain of intramuscular injection of penicillin, and is also used in dentistry.Owing to the ubiquity of the trade name Novocain, procaine is sometimes referred to generically as novocaine.. Procaine was first synthesized in 1898, and was the first injectable man-made local anesthetic.  Racine R, et al. 0.5 mM Procaine blocks individual sarcoplasmic reticulum Ca2+ release channels in planarlipid bilayers. Tel: +1-832-582-8158 Fax: +1-832-582-8590Email:[email protected], Tel: +49-89-46148500 Fax: +49-89-461485022Email:[email protected]. 0.5 mM Procaine produces a 40% reduction in 5-methylcytosine DNA in MCF-7 breast cancer cell line.
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